Publications: (link to Harvard Catalyst Profile) 

1: Guadagnin E, Bagchi D, Sinha I, Neppl RL. Nuclear localized Akt limits skeletal muscle derived fibrotic signaling. Biochem Biophys Res Commun. 2018 Dec 7. pii: S0006-291X(18)32640-8. doi: 10.1016/j.bbrc.2018.11.202. [Epub ahead of print] PubMed PMID: 30528731.

2: Panayi AC, Orkaby AR, Sakthivel D, Endo Y, Varon D, Roh D, Orgill DP, Neppl RL, Javedan H, Bhasin S, Sinha I. Impact of frailty on outcomes in surgical patients: A systematic review and meta-analysis. Am J Surg. 2018 Nov 27. pii: S0002-9610(18)31242-X. doi: 10.1016/j.amjsurg.2018.11.020. [Epub ahead of print] PubMed PMID: 30509455.

3: Neppl RL, Wu CL, Walsh K. lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy. J Cell Biol. 2017 Nov 6;216(11):3497-3507. doi: 10.1083/jcb.201612100. Epub 2017 Aug 30. PubMed PMID: 28855249; PubMed Central PMCID: PMC5674882.

4: Neppl RL, Wang DZ. The myriad essential roles of microRNAs in cardiovascular homeostasis and disease. Genes Dis. 2014 Mar 1;1(1):18-39. PubMed PMID: 25328909; PubMed Central PMCID: PMC4200483.

5: Neppl RL, Kataoka M, Wang DZ. Crystallin-αB regulates skeletal muscle homeostasis via modulation of argonaute2 activity. J Biol Chem. 2014 Jun 13;289(24):17240-8. doi: 10.1074/jbc.M114.549584. Epub 2014 Apr 29. PubMed PMID: 24782307; PubMed Central PMCID: PMC4059164.

6: Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. 2011 Aug 22;194(4):551-65. doi: 10.1083/jcb.201010090. PubMed PMID: 21859860; PubMed Central PMCID: PMC3160588.

7: Neppl RL, Wang DZ. 'CArG'ing for microRNAs. Gastroenterology. 2011 Jul;141(1):24-7. doi: 10.1053/j.gastro.2011.05.021. Epub 2011 May 26. PubMed PMID: 21620846.

8: Zieba BJ, Artamonov MV, Jin L, Momotani K, Ho R, Franke AS, Neppl RL, Stevenson AS, Khromov AS, Chrzanowska-Wodnicka M, Somlyo AV. The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. J Biol Chem. 2011 May 13;286(19):16681-92. doi: 10.1074/jbc.M110.205062. Epub 2011 Mar 25. PubMed PMID: 21454546; PubMed Central PMCID: PMC3089510.

9: Hoofnagle MH, Neppl RL, Berzin EL, Teg Pipes GC, Olson EN, Wamhoff BW, Somlyo AV, Owens GK. Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes. Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1707-21. doi: 10.1152/ajpheart.01192.2010. Epub 2011 Feb 25. PubMed PMID: 21357509; PubMed Central PMCID: PMC3094091.

10: Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011 Feb 1;25(3):263-74. doi: 10.1101/gad.2018511. PubMed PMID: 21289070; PubMed Central PMCID: PMC3034901.

11: Huang ZP, Neppl RL Jr, Wang DZ. Application of microRNA in cardiac and skeletal muscle disease gene therapy. Methods Mol Biol. 2011;709:197-210. doi: 10.1007/978-1-61737-982-6_12. PubMed PMID: 21194029; PubMed Central PMCID: PMC4886235.

12: Huang ZP, Neppl RL, Wang DZ. MicroRNAs in cardiac remodeling and disease. J Cardiovasc Transl Res. 2010 Jun;3(3):212-8. doi: 10.1007/s12265-010-9165-y. Epub 2010 Feb 17. Review. PubMed PMID: 20560042.

13: Neppl RL, Wang DZ. MicroRNAs in cardiovascular disease. Encyclopedia of Life Sciences (ELS). 2010 Jun 17. [doi: 10.1002/9780470015902.a0022431]

14: Neppl RL, Wang DZ. Smooth(ing) muscle differentiation by microRNAs. Cell Stem Cell. 2009 Aug 7;5(2):130-2. doi: 10.1016/j.stem.2009.07.004. PubMed PMID: 19664984; PubMed Central PMCID: PMC4285345.

15: Neppl RL, Lubomirov LT, Momotani K, Pfitzer G, Eto M, Somlyo AV. Thromboxane A2-induced bi-directional regulation of cerebral arterial tone. J Biol Chem. 2009 Mar 6;284(10):6348-60. doi: 10.1074/jbc.M807040200. Epub 2008 Dec 17. PubMed PMID: 19095646; PubMed Central PMCID: PMC2649081.

16: Wooldridge AA, Fortner CN, Lontay B, Akimoto T, Neppl RL, Facemire C, Datto MB, Kwon A, McCook E, Li P, Wang S, Thresher RJ, Miller SE, Perriard JC, Gavin TP, Hickner RC, Coffman TM, Somlyo AV, Yan Z, Haystead TA. Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem. 2008 Apr 25;283(17):11850-9. doi: 10.1074/jbc.M708628200. Epub 2008 Feb 29. PubMed PMID: 18310078; PubMed Central PMCID: PMC2431077.

17: Sinha S, Wamhoff BR, Hoofnagle MH, Thomas J, Neppl RL, Deering T, Helmke BP, Bowles DK, Somlyo AV, Owens GK. Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells. Stem Cells. 2006 Jul;24(7):1678-88. Epub 2006 Apr 6. PubMed PMID: 16601077.

18: Neppl R, Nguyen CM, Bowen W, Al-Saadi T, Pallagi J, Morris G, Mueller W, Johnson R, Prost R, Rand SD. In vivo detection of postictal perturbations of cerebral metabolism by use of proton MR spectroscopy: preliminary results in a canine model of prolonged generalized seizures. AJNR Am J Neuroradiol. 2001 Nov-Dec;22(10):1933-43. PubMed PMID: 11733328.

19: Butzen J, Prost R, Chetty V, Donahue K, Neppl R, Bowen W, Li SJ, Haughton V, Mark L, Kim T, Mueller W, Meyer G, Krouwer H, Rand S. Discrimination between neoplastic and nonneoplastic brain lesions by use of proton MR spectroscopy: the limits of accuracy with a logistic regression model. AJNR Am J Neuroradiol. 2000 Aug;21(7):1213-9. PubMed PMID: 10954271.